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- Title
A targeted nanoplatform co-delivery of pooled siRNA and doxorubicin for reversing of multidrug resistance in breast cancer.
- Authors
Liu, Hongmei; Ma, Ding; Chen, Jinpeng; Ye, Li; Li, Yiping; Xie, Yuexia; Zhao, Xue; Zou, Hanbing; Chen, Xiaojing; Pu, Jun; Liu, Peifeng
- Abstract
Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer patients receiving traditional chemotherapeutics or novel targeted drugs. Here, we developed a targeted nanoplatform based on biodegradable boronic acid modified ε-polylysine to co-deliver P-gp siRNA, Bcl-2 siRNA, and doxorubicin for overcoming the challenge. The targeted nanoplatform showed a robust suppressing efficiency for the invasion, proliferation, and colony formation of adriamycin (ADR) resistant breast cancer cell line (MCF-7/ADR) cells in vitro. The ATP responsiveness of the nanoplatform was also proved in the research. In the in vivo antitumor experiment, the targeted nanoplatform showed a significant inhibition of tumor growth with good biocompatibility. The goal of this study is to develop a novel and facile strategy to prepare a highly efficient and safe gene and drug delivery system for MDR breast cancer based on biocompatible ε-polylysine polymers.
- Publication
Nano Research, 2022, Vol 15, Issue 7, p6306
- ISSN
1998-0124
- Publication type
Article
- DOI
10.1007/s12274-022-4254-1