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- Title
Ranibizumab for the treatment of degenerative ocular conditions.
- Authors
Triantafylla, Magdalini; Massa, Horace F.; Dardabounis, Doukas; Gatzioufas, Zisis; Kozobolis, Vassilios; Ioannakis, Konstantinos; Perente, Irfan; Panos, Georgios D.
- Abstract
Degenerative ocular conditions, such as age-related macular degeneration, diabetic retinopathy, retinal vein occlusions, and myopic degeneration, have become a major public health problem and a leading cause of blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) drugs seem to be an effective and safe treatment for these conditions. Ranibizumab, a humanized monoclonal antibody antigen-binding fragment, which inhibits all biologically active isoforms of VEGF-A, is still the gold standard treatment for the majority of these pathological entities. In this review, we present the results of the most important clinical trials concerning the efficacy and safety of ranibizumab for the treatment of degenerative ocular conditions.
- Subjects
RANIBIZUMAB; EYE diseases; RETINAL degeneration; DIABETIC retinopathy; VASCULAR endothelial growth factors; IMMUNOGLOBULINS
- Publication
Clinical Ophthalmology, 2014, Vol 8, p1187
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S40350