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- Title
A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations.
- Authors
Zhang, Jing; Kang, June; Dehghan, Shoaleh; Sridhar, Siddharth; Lau, Susanna K. P.; Ou, Junxian; Woo, Patrick C. Y.; Zhang, Qiwei; Seto, Donald
- Abstract
Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these "old" HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian populations contain NF-I, indicating recombination and reflecting host-adaptation that enables the "new" HAdV-E4 to replicate more efficiently in human cells and foretells more potential HAdV-E4 outbreaks in immune-naïve civilian populations. Special attention should be paid by clinicians to this emergent and recombinant HAdV-E4 circulating in civilian populations.
- Subjects
PATHOGENIC microorganisms; GENOMES; HUMAN adenoviruses; ADENOVIRUSES; CHIMPANZEES
- Publication
Viruses (1999-4915), 2019, Vol 11, Issue 2, p129
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v11020129