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- Title
Fetal Brain Infection Is Not a Unique Characteristic of Brazilian Zika Viruses.
- Authors
Setoh, Yin Xiang; Peng, Nias Y.; Nakayama, Eri; Amarilla, Alberto A.; Prow, Natalie A.; Suhrbier, Andreas; Khromykh, Alexander A.
- Abstract
The recent emergence of Zika virus (ZIKV) in Brazil was associated with an increased number of fetal brain infections that resulted in a spectrum of congenital neurological complications known as congenital Zika syndrome (CZS). Herein, we generated de novo from sequence data an early Asian lineage ZIKV isolate (ZIKV-MY; Malaysia, 1966) not associated with microcephaly and compared the in vitro replication kinetics and fetal brain infection in interferon α/β receptor 1 knockout (IFNAR1−/−) dams of this isolate and of a Brazilian isolate (ZIKV-Natal; Natal, 2015) unequivocally associated with microcephaly. The replication efficiencies of ZIKV-MY and ZIKV-Natal in A549 and Vero cells were similar, while ZIKV-MY replicated more efficiently in wild-type (WT) and IFNAR−/− mouse embryonic fibroblasts. Viremias in IFNAR1−/− dams were similar after infection with ZIKV-MY or ZIKV-Natal, and importantly, infection of fetal brains was also not significantly different. Thus, fetal brain infection does not appear to be a unique feature of Brazilian ZIKV isolates.
- Subjects
ZIKA virus; FETAL brain abnormalities; COMMUNICABLE diseases; MICROCEPHALY; CRANIOFACIAL abnormalities
- Publication
Viruses (1999-4915), 2018, Vol 10, Issue 10, p541
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v10100541