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- Title
Translational Control of the HIV Unspliced Genomic RNA.
- Authors
Rojas-Araya, Bárbara; Ohlmann, Théophile; Soto-Rifo, Ricardo
- Abstract
Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.
- Subjects
HIV infection genetics; CELL nuclei; VIRAL proteins; CYTOPLASM; RNA splicing; NUCLEOPROTEINS
- Publication
Viruses (1999-4915), 2015, Vol 7, Issue 8, p4326
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v7082822