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- Title
Neutralization Interfering Antibodies: A "Novel" Example of Humoral Immune Dysfunction Facilitating Viral Escape?
- Authors
Nicasio, Mancini; Sautto, Giuseppe; Clementi, Nicola; Diotti, Roberta A.; Criscuolo, Elena; Castelli, Matteo; Solforosi, Laura; Clementi, Massimo; Burioni, Roberto
- Abstract
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this "novel" evasion strategy.
- Subjects
PATHOGENIC microorganisms; IMMUNE response; ANTIGEN-antibody reactions; CELLULAR immunity; IMMUNOLOGY
- Publication
Viruses (1999-4915), 2012, Vol 4, Issue 9, p1731
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v4091731