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- Title
A Bioactive Degradable Composite Bone Cement Based on Calcium Sulfate and Magnesium Polyphosphate.
- Authors
Peng, Suping; Yang, Xinyue; Zou, Wangcai; Chen, Xiaolu; Deng, Hao; Zhang, Qiyi; Yan, Yonggang
- Abstract
Calcium sulfate bone cement (CSC) is extensively used as a bone repair material due to its ability to self-solidify, degradability, and osteogenic ability. However, the fast degradation, low mechanical strength, and insufficient biological activity limit its application. This study used magnesium polyphosphate (MPP) and constructed a composite bone cement composed of calcium sulfate (CS), MPP, tricalcium silicate (C3S), and plasticizer hydroxypropyl methylcellulose (HPMC). The optimized CS/MPP/C3S composite bone cement has a suitable setting time of approximately 15.0 min, a compressive strength of 26.6 MPa, and an injectability of about 93%. The CS/MPP/C3S composite bone cement has excellent biocompatibility and osteogenic capabilities; our results showed that cell proliferation is up to 114% compared with the control after 5 days. After 14 days, the expression levels of osteogenic-related genes, including Runx2, BMP2, OCN, OPN, and COL-1, are about 1.8, 2.8, 2.5, 2.2, and 2.2 times higher than those of the control, respectively, while the alkaline phosphatase activity is about 1.7 times higher. Therefore, the CS/MPP/C3S composite bone cement overcomes the limitations of CSC and has more effective potential in bone repair.
- Subjects
CEMENT composites; CALCIUM sulfate; BONE cements; POLYMETHYLMETHACRYLATE; MAGNESIUM sulfate; DENTAL cements; ALKALINE phosphatase
- Publication
Materials (1996-1944), 2024, Vol 17, Issue 8, p1861
- ISSN
1996-1944
- Publication type
Article
- DOI
10.3390/ma17081861