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- Title
Infant exposure to Chinese famine increased the risk of hypertension in adulthood: results from the China Health and Retirement Longitudinal Study.
- Authors
Zhenghe Wang; Changwei Li; Zhongping Yang; Zhiyong Zou; Jun Ma; Wang, Zhenghe; Li, Changwei; Yang, Zhongping; Zou, Zhiyong; Ma, Jun
- Abstract
<bold>Background: </bold>Early-life developmental adaptations in response to severe malnutrition may play a crucial role in susceptibility to hypertension. This study aimed to explore the associations between exposure to the Chinese famine (1959-1961) at fetal, infant and preschool stages during fetal life or childhood and the risk of hypertension in adulthood.<bold>Methods: </bold>We used the data of 1,966 adults born between 1956 and 1964 in selected families from the China Health and Retirement Longitudinal Study (CHARLS) national survey.<bold>Results: </bold>Prevalence of hypertension among adults in non-exposed, fetal-exposed, infant-exposed, and preschool-exposed cohorts was 18.9, 20.7, 28.7, and 23.4 %, respectively. In severely affected famine areas, only infant-exposed cohort had a significant increased risk of hypertension compared with non-exposed cohort (OR 2.12; 95 % CI 1.19, 3.79; P = 0.011), and the significance remained after adjusted gender, smoking, and drinking (OR 2.11; 95 % CI 1.18, 3.77; P = 0.012). After stratification by BMI and economic status, the risk of hypertension was higher for subjects with BMI ≥ 24 kg/m(2)(OR 2.09; 95 % CI 1.09, 4.01; P = 0.026) or high economic status(OR 2.26; 95 % CI 1.19, 4.31; P = 0.013) than those with BMI < 24 kg/m(2)(OR 1.65; 95 % CI 0.71, 3.83; P = 0.246) or low economic status (OR 2.18; 95 % CI 1.14, 4.18; P = 0.019) in infant-exposed cohort of severely affected famine areas. However, there was no consistent association observed in less severely affected area or other exposed cohorts in severely affected areas.<bold>Conclusions: </bold>Infanthood exposed to famine might increase the risk of hypertension in adulthood, and a postnatal 'rich' nutrient environment further increased the risk.
- Subjects
CHINA; HYPERTENSION risk factors; MALNUTRITION; FAMINES; HEALTH &; economic status; HYPERTENSION in adolescence; LONGITUDINAL method; HYPERTENSION epidemiology; AGE distribution; LABOR (Obstetrics); STARVATION; SURVEYS; SOCIOECONOMIC factors; BODY mass index; RELATIVE medical risk; DISEASE prevalence; PRENATAL exposure delayed effects
- Publication
BMC Public Health, 2016, Vol 161, Issue 1, p1
- ISSN
1471-2458
- Publication type
journal article
- DOI
10.1186/s12889-016-3122-x