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- Title
Non-A, non-B hepatitis and antibody to hepatitis C virus.
- Authors
Mosley, J W; Aach, R D; Hollinger, F B; Stevens, C E; Barbosa, L H; Nemo, G J; Holland, P V; Bancroft, W H; Zimmerman, H J; Kuo, G
- Abstract
Stored serum samples from the Transfusion-transmitted Viruses Study in the 1970s were tested for the presence of antibody to hepatitis C virus (anti-HCV). Single specimens from five control subjects who did not receive transfusions tested negative for anti-HCV. Of four control subjects who did not receive transfusions and who developed non-A, non-B (NANB) hepatitis after hospitalization, three remained anti-HCV negative; the fourth person with postoperative NANB hepatitis tested anti-HCV positive before the operation. Five transfusion recipients with posttransfusion hepatitis B virus infection remained seronegative; a sixth with NANB hepatitis as well as hepatitis B virus infection had seroconversion for anti-HCV. Five of nine transfusion recipients with NANB hepatitis had anti-HCV seroconversion. These results show that present anti-HCV testing demonstrates an etiologic basis for approximately half of the cases of transfusion-associated NANB hepatitis, particularly those that develop chronicity. Although cases of NANB hepatitis without seroconversion may be explained otherwise, they may be caused by another, presently unidentified, virus.
- Subjects
BLOOD transfusion; COMPARATIVE studies; HEPATITIS C; VIRAL hepatitis; RESEARCH methodology; MEDICAL cooperation; RESEARCH; VIRAL antibodies; EVALUATION research
- Publication
JAMA: Journal of the American Medical Association, 1990, Vol 263, Issue 1, p77
- ISSN
0098-7484
- Publication type
journal article
- DOI
10.1001/jama.263.1.77