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- Title
Rapid Inverse Planning for Pressure-Driven Drug Infusions in the Brain.
- Authors
Rosenbluth, Kathryn H.; Martin, Alastair J.; Mittermeyer, Stephan; Eschermann, Jan; Dickinson, Peter J.; Bankiewicz, Krystof S.
- Abstract
Infusing drugs directly into the brain is advantageous to oral or intravenous delivery for large molecules or drugs requiring high local concentrations with low off-target exposure. However, surgeons manually planning the cannula position for drug delivery in the brain face a challenging three-dimensional visualization task. This study presents an intuitive inverse-planning technique to identify the optimal placement that maximizes coverage of the target structure while minimizing the potential for leakage outside the target. The technique was retrospectively validated using intraoperative magnetic resonance imaging of infusions into the striatum of non-human primates and into a tumor in a canine model and applied prospectively to upcoming human clinical trials.
- Subjects
DRUG infusion pumps; BRAIN physiology; MAGNETIC resonance imaging of the brain; NEUROPHARMACOLOGY; VETERINARY medicine; COMPUTER simulation; CLINICAL trials
- Publication
PLoS ONE, 2013, Vol 8, Issue 2, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0056397