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- Title
Anxiety and cognitive-related effects of Δ <sup>9</sup>-tetrahydrocannabinol (THC) are differentially mediated through distinct GSK-3 vs. Akt-mTOR pathways in the nucleus accumbens of male rats.
- Authors
Hudson, Roger; Norris, Christopher; Szkudlarek, Hanna J.; Khan, Dinat; Schmid, Susanne; Rushlow, Walter J.; Laviolette, Steven R.
- Abstract
Rationale: Δ9-tetrahydrocannabinol (THC) is the primary psychoactive compound in cannabis and is responsible for cannabis-related neuropsychiatric side effects, including abnormal affective processing, cognitive and sensory filtering deficits and memory impairments. A critical neural region linked to the psychotropic effects of THC is the nucleus accumbens shell (NASh), an integrative mesocorticolimbic structure that sends and receives inputs from multiple brain areas known to be dysregulated in various disorders, including schizophrenia and anxiety-related disorders. Considerable evidence demonstrates functional differences between posterior vs. anterior NASh sub-regions in the processing of affective and cognitive behaviours influenced by THC. Nevertheless, the neuroanatomical regions and local molecular pathways responsible for these psychotropic effects are not currently understood. Objectives: The objectives of this study were to characterize the effects of intra-accumbens THC in the anterior vs. posterior regions of the NASh during emotional memory formation, sensorimotor gating and anxiety-related behaviours. Methods: We performed an integrative series of translational behavioural pharmacological studies examining anxiety, sensorimotor gating and fear-related associative memory formation combined with regionally specific molecular signalling analyses in male Sprague Dawley rats. Results: We report that THC in the posterior NASh causes distortions in emotional salience attribution, impaired sensory filtering and memory retention and heightened anxiety, through a glycogen-synthase-kinase-3 (GSK-3)-β-catenin dependent signalling pathway. In contrast, THC in the anterior NASh produces anxiolytic effects via modulation of protein kinase B (Akt) phosphorylation states. Conclusions: These findings reveal critical new insights into the neuroanatomical and molecular mechanisms associated with the differential neuropsychiatric side effects of THC in dissociable nucleus accumbens sub-regions.
- Subjects
NUCLEUS accumbens; ANXIETY; CANNABIDIOL; PROTEIN kinase B; SPRAGUE Dawley rats; SENSORY memory; MEMORY disorders; HYDROCARBON metabolism; PROTEIN kinases; BIOLOGICAL models; MEMORY; ANIMAL behavior; GROWTH factors; BASAL ganglia; ANIMAL experimentation; LARGE-scale brain networks; COGNITION; METABOLISM; CYTOSKELETAL proteins; CELLULAR signal transduction; RATS; MOLECULAR biology; CANNABINOIDS; EMOTIONS; NEUROANATOMY; PHOSPHORYLATION
- Publication
Psychopharmacology, 2022, Vol 239, Issue 2, p509
- ISSN
0033-3158
- Publication type
Article
- DOI
10.1007/s00213-021-06029-w