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- Title
The Role of Cell-Free Fetal DNA as a Preventative Attempt to Decrease the Severity of Genetic Disorders: A Review.
- Authors
Sosiawan, Agung; Kurniati, Mala; Pramono D., R. M. Coen; Mulyawan, Indra; Furqoni, Abdul Hadi; Nuraini, Indah; A'yun, Qurrota
- Abstract
The development of prenatal diagnosis has developed very rapidly over decades. Prenatal screening is applied to a mother with high-risk pregnancy (threatening the life of the fetus), such as a too-old mother or a too-young mother and having a certain disease in her medical history. Up until now, the curative method to treat genetic disorder is still developed and perfected. Therefore, a preventative action during pregnancy is important to do, such as Noninvasive Prenatal Testing (NIPT). NIPT method that is widely developed is the circulating cell-free fetal DNA (cffDNA) testing that can be useful for determining the fetal gender, the identification of specific single-gene disorders, blood type, paternity determination, and the potency of regular use for testing chromosomal abnormalities. The detection of cell-free fetal DNA in the maternal blood circulation provides a new expectation for NIPT, especially preventing the severity of genetic disorders.
- Subjects
X-linked genetic disorders; PRENATAL diagnosis; GENETIC testing; PREVENTIVE health services; CHROMOSOME abnormalities; EXTRACELLULAR space; NUCLEIC acids; PREGNANCY
- Publication
Medico-Legal Update, 2021, Vol 21, Issue 2, p18
- ISSN
0971-720X
- Publication type
Article
- DOI
10.37506/mlu.v21i2.2638