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- Title
Synthesis of New Drug Carriers of Metronidazoleas Antifungal Agents.
- Authors
Al-lami, Naeemah J.; Jassim, Zaina; Muhamad, Yasmeen H.; jaffer, Mahdi
- Abstract
New drug carriers were synthesised through etherification with sugar moiety and metronidazole drug. The synthetic pathway was started with two sugars, β-D-glucose and β-D-fructose, which were protected as peracetate and benzoate respectively, then converted to bromo sugar. The bromo sugars were subjected to coupling with metronidazole drug via Willemenson reaction to afford protected drug carriers. All prepared compounds were characterised via FT-IR, ½H-NMR and 13C-NMR and HR-MS spectroscopy. These new carriers were tested against four types of fungi kandida yeast. Some of tested compounds showed moderate activity while the other showed weak inhibition. Interestingly, two carrier drugs showed high activity against fungi.
- Subjects
DRUG delivery systems; ANTIFUNGAL agents; PRODRUGS; ETHERS; CANDIDA; NUCLEAR magnetic resonance spectroscopy; METRONIDAZOLE; YEAST; CARBOHYDRATES; MASS spectrometry; INFRARED spectroscopy; ANALYTICAL chemistry
- Publication
Medico-Legal Update, 2020, Vol 20, Issue 4, p974
- ISSN
0971-720X
- Publication type
Article
- DOI
10.37506/mlu.v20i4.1951