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- Title
Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals.
- Authors
Rotstein, David S.; Peloquin, Sarah; Proia, Kathleen; Hart, Ellen; Lee, Jeongha; Vyhnal, Kristin K.; Sasaki, Emi; Balamayooran, Gayathriy; Asin, Javier; Southard, Teresa; Rothfeldt, Laura; Venkat, Heather; Mundschenk, Peter; McDermott, Darby; Crossley, Beate; Ferro, Pamela; Gomez, Gabriel; Henderson, Eileen H.; Narayan, Paul; Paulsen, Daniel B.
- Abstract
Documented natural infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in exotic and companion animals following human exposures are uncommon. Those documented in animals are typically mild and self-limiting, and infected animals have only infrequently died or been euthanized. Through a coordinated One Health initiative, necropsies were conducted on 5 animals from different premises that were exposed to humans with laboratory-confirmed SARS-CoV-2 infection. The combination of epidemiologic evidence of exposure and confirmatory real-time reverse transcriptase-polymerase chain reaction testing confirmed infection in 3 cats and a tiger. A dog was a suspect case based on epidemiologic evidence of exposure but tested negative for SARS-CoV-2. Four animals had respiratory clinical signs that developed 2 to 12 days after exposure. The dog had bronchointerstitial pneumonia and the tiger had bronchopneumonia; both had syncytial-like cells with no detection of SARS-CoV-2. Individual findings in the 3 cats included metastatic mammary carcinoma, congenital renal disease, and myocardial disease. Based on the necropsy findings and a standardized algorithm, SARS-CoV-2 infection was not considered the cause of death in any of the cases. Continued surveillance and necropsy examination of animals with fatal outcomes will further our understanding of natural SARS-CoV-2 infection in animals and the potential role of the virus in development of lesions.
- Subjects
COVID-19; EXOTIC animals; TIGERS; PETS; SARS-CoV-2; CATS
- Publication
Veterinary Pathology, 2022, Vol 59, Issue 4, p707
- ISSN
0300-9858
- Publication type
Article
- DOI
10.1177/03009858211067467