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- Title
Improved Synthesis of the Triazacryptand (TAC) and its Application in the Construction of a Fluorescent TAC-BODIPY Conjugate for K<sup>+</sup> Sensing in Live Cells.
- Authors
Sui, Binglin; Yue, Xiling; Tichy, Michael G.; Liu, Taihong; Belfield, Kevin D.
- Abstract
In this report, a vastly improved method for the synthesis of [2.2.3]-triazacryptand (TAC), an excellent K+-selective cryptand, is disclosed, which provides a shorter synthetic route with > fivefold higher overall yield. On the basis of the improved synthesis, a TAC-BODIPY conjugate was developed for K+ sensing. TAC-BODIPY is a fluorescence turn-on K+ sensor exhibiting high selectivity toward K+ over other biologically relevant metal cations. Cell imaging studies are presented and demonstrate that TAC-BODIPY is suitable for dynamic K+ sensing in live cells.
- Subjects
TRIAZANES; CRYPTANDS; CATIONS; MOLECULAR structure of ligands; QUORUM sensing
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 6, p1189
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201403600