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- Title
Immunological Aspects in Migraine: Increase of IL-10 Plasma Levels During Attack.
- Authors
Munno, I.; Marinaro, M.; Bassi, A.; Cassiano, M.A.; Causarano, V.; Centonze, V.
- Abstract
In the present study, 23 patients with migraine without aura were monitored during a migraine attack. Plasma levels of interleukin (IL)-4, IL-5, IL-10, and interferon-γ were measured by enzyme-linked immunosorbent assay techniques. Interestingly, we observed low to undetectable IL-5 and IL-4 levels, whereas high IL-10 levels were seen in 52.2% of the patients. Interferon-γ plasma levels were undetectable in all patients. After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL-10 and an increase in both IL-4 and IL-5 plasma levels. Although these findings are derived from a limited number of patients, the apparent return to the IL-4 and IL-5 cytokine profile observed during the interictal period leads us to speculate that a preferential enhancement of TH2-type cytokine production may contribute to the pathogenesis of migraine.
- Subjects
INTERLEUKINS; INTERFERONS; GRANULOCYTE-macrophage colony-stimulating factor
- Publication
Headache: The Journal of Head & Face Pain, 2001, Vol 41, Issue 8, p764
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1046/j.1526-4610.2001.01140.x