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- Title
Carbon dioxide water-bath treatment augments peripheral blood flow through the development of angiogenesis.
- Authors
Xu, Yan-Jun; Elimban, Vijayan; Dhalla, Naranjan S.
- Abstract
In this study, we investigated the effects of CO2 water-bath therapy on blood flow and angiogenesis in the ischemic hind limb, as well as some plasma angiogenic factors in peripheral ischemic model. The hind limb ischemia was induced by occluding the femoral artery for 2 weeks in rats and treated with or without CO2 water-bath therapy at 37 °C for 4 weeks (20 min treatment every day for 5 days per week). The peak blood flow and minimal and mean blood flow in the ischemic skeletal muscle were markedly increased by the CO2 water-bath therapy. This increase in blood flow was associated with development of angiogenesis in the muscle, as well as reduction in the ischemia-induced increase in plasma malondialdehyde levels. Although plasma vascular endothelial growth factor and nitric oxide levels were increased in animals with peripheral ischemia, the changes in these biomarkers were not affected by CO2 water-bath therapy. These results suggest that augmentation of blood flow in the ischemic hind limb by CO2 water-bath therapy may be due to the development of angiogenesis and reduction in oxidative stress.
- Subjects
CARBON dioxide; BLOOD flow; NEOVASCULARIZATION; HINDLIMB; VASCULAR endothelial growth factors
- Publication
Canadian Journal of Physiology & Pharmacology, 2017, Vol 95, Issue 8, p938
- ISSN
0008-4212
- Publication type
Article
- DOI
10.1139/cjpp-2017-0125