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- Title
A "neat" synthesis of substituted 2-hydroxy-pyrido[1,2-a]pyrimidin-4-ones.
- Authors
Gaube, Gregory; Mutter, James; Leitch, David C.
- Abstract
We report the synthesis of a series of substituted 2-hydroxy-pyrido[1,2-a]pyrimidin-4-ones through a condensation of 2-aminopyridines and diethyl malonate. This method is contrasted with three reported general procedures for the preparation of these compounds, revealing that simple, "neat" synthesis conditions are suitable for a number of derivatives, including halogenated compounds suitable for further functionalization. Environmental, safety, and economic factors were considered in exploring this effective and robust synthetic method.
- Subjects
ECONOMIC impact; CONDENSATION
- Publication
Canadian Journal of Chemistry, 2024, Vol 102, Issue 4, p206
- ISSN
0008-4042
- Publication type
Article
- DOI
10.1139/cjc-2023-0150