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- Title
IGF-I Receptor Is Required for the Anabolic Actions of Parathyroid Hormone on Bone.
- Authors
Yongmei Wang; Nishida, Shigeki; Boudignon, Benjamin M.; Burghardt, Andrew; Elalieh, Hashem Z.; Hamilton, Michelle M.; Majumdar, Sharmila; Halloran, Bernard P.; Clemens, Thomas L.; Bikie, Daniel D.
- Abstract
The article discusses the role of insulin-like growth factor protein-1 (IGF-I) receptor as a mediator of the parathyroid hormone (PTH) in mature osteoblasts. The study used IGF-IR OBKO mice, or mice in which IGF-IR gene was selectively deleted in mature osteoblasts. Results showed that the deletion of IGF-IR in the mature osteoblasts blunted the anabolic effects of PTH. It was concluded that IGF-IR is involved in mediating the anabolic actions of PTH and is needed for normal bone remodeling.
- Subjects
INSULIN-like growth factor-binding proteins; PARATHYROID hormone-related protein; BONE growth; OSTEOCYTES; CELL receptors
- Publication
Journal of Bone & Mineral Research, 2007, Vol 22, Issue 9, p1329
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.070517