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- Title
Alternative splicing in mesenchymal stem cell differentiation.
- Authors
Park, Jung Woo; Fu, Siyi; Huang, Borong; Xu, Ren‐He
- Abstract
The differentiation and maturation of mesenchymal stem cells (MSCs) to mesodermal and other lineages are known to be controlled by various extrinsic and intrinsic signals. The dysregulation of the MSC differentiation balance has been linked to several pathophysiological conditions, including obesity and osteoporosis. Previous research of the molecular mechanisms governing MSC differentiation has mostly focused on transcriptional regulation. However, recent findings are revealing the underrated role of alternative splicing (AS) in MSC differentiation and functions. In this review, we discuss recent progress in elucidating the regulatory roles of AS in MSC differentiation. We catalogue and highlight the key AS events that modulate MSC differentiation to major osteocytes, chondrocytes, and adipocytes, and discuss the regulatory mechanisms by which AS is regulated.
- Subjects
MESENCHYMAL stem cells; CELL differentiation; OSTEOPOROSIS; RNA-binding proteins; ALTERNATIVE RNA splicing
- Publication
Stem Cells, 2020, Vol 38, Issue 10, p1229
- ISSN
1066-5099
- Publication type
Article
- DOI
10.1002/stem.3248