We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Human la-Like Antigens Associated with HLA-D.
- Authors
Albrechtsen, D.; Solheim, B. G.; Thorsby, E.
- Abstract
Antisera raised within HLA-A - and -B-compatible, HLA-D -disparate combinations were cytotoxic to B lymphocytes from the immunizing donor and to B lymphocytes from most or all cell donors sharing the immunizing donor's HLA-D phenotype. Four antisera recognized structures closely associated with the HLA-D determinants Dw2, Dw3, Dw4, and LD 108. One antiserum had a broad reactivity pattern, including Dw3, Dw6, and some unknown specificity(ies). In population and family studies these B-lymphocyte antigens behaved as if they were governed by one genetic locus in the B-D region of the HLA complex. Furthermore, the antisera were cytotoxic to a minor concanavalin-A-reactive T-cell subpopulation. The antisera had previously been shown to inhibit the stimulating cells in mixed lymphocyte culture and to he capable of inhibiting the Fc receptor in the EA rosette assay. We conclude that the antisera produced by this method recognize Ia-like antigens closely associated with the FILA-D determinants.
- Subjects
IMMUNE serums; B cells; LYMPHOCYTES; ANTIGENS; IMMUNOGLOBULINS; CELL receptors
- Publication
Scandinavian Journal of Immunology, 1977, Vol 6, Issue 5, p419
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1977.tb02098.x