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- Title
Comparative Study of Antibody-Dependent and Direct Lymphocyte-Mediated Cytotoxicity In Vitro After Alloimmunization in the Human I. Kinetics and the Effect of Anti-Immunoglobulins.
- Authors
Dickmeiss, E.
- Abstract
Two major types of cell-mediated cytotoxicity in vitro after alloimmunization in the human have been described--antibody-dependent lymphocyte-mediated cytotoxicity (ADLC) and direct immune-lymphocyte-mediated cytotoxicity (DLC). The characteristics of these two in vitro systems are compared. The cytolysis occurred as a linear function of time in both cases. The effector cell dose response relationship was in both systems well described by a linear correlation between the logarithm of the effector cell dose and the cytotoxic activity. Anti-immunoglobulins inhibited ADLC but not DLC. The reactivity in DLC was potentiated by the addition of isoantibody directed against target cells.
- Subjects
PLASMA cells; CELL-mediated cytotoxicity; BLOOD proteins; IMMUNOGLOBULINS; KILLER cells; CELL death
- Publication
Scandinavian Journal of Immunology, 1974, Vol 3, Issue 6, p809
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1974.tb01316.x