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- Title
Studies on the Induction of Antibody Synthesis against Sulfanilic Acid in Rabbits III. Effect of Antibodies Directed against New Antigenic Determinants in Homologous Protein. The Effect in Primed or Unresponsive Rabbits.
- Authors
Rubin, B.
- Abstract
The following three results emerged from the present experiments concerning the induction of antibody synthesis against sulfanilic acid: 1) the anti-Sulf antibody response in rabbits seems to be much more carrier-dependent when Sulf is coupled to heterologous serum protein compared to homologous (autologous) serum protein; 2) anti-NAD antibodies (antibodies directed against the new antigenic determinants introduced into the carrier through the coupling with hapten) were able to induce a secondary response to Sulf11RSA in rabbits primarily stimulated with Sulf10BGG; and 3) anti-NAD antibodies were able to induce an immune response to Sulf11RSA in rabbits made unresponsive to Sulf11RSA by i.v. injections of soluble Sulf11RSA.
- Subjects
IMMUNOGLOBULINS; LABORATORY rabbits; BLOOD proteins; EPITOPES; IMMUNE response
- Publication
Scandinavian Journal of Immunology, 1972, Vol 1, Issue 2, p135
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1972.tb00592.x