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- Title
Role of metastasis-directed treatment in kidney cancer.
- Authors
Psutka, Sarah P.; Master, Viraj A.
- Abstract
Despite the rapid elaboration of multiple, novel systemic agents introduced for metastatic renal cell carcinoma (mRCC) in recent years, a durable complete response remains elusive with systemic therapy alone. Definitive treatment of the metastatic deposit remains the sole potentially curative option and is a cornerstone of mRCC therapy, offering potential for both local control and palliation of tumor-related symptoms. In this review, the evidence supporting the definitive treatment of mRCC is examined and summarized, including the use of surgical metastasectomy, thermal ablation, radiotherapy, and other minimally invasive options. Multimodal approaches, including the combination of metastasectomy with novel systemic agents, are discussed. Finally, the authors review considerations for patient selection for this type of therapy and summarize available risk-stratification tools that may help guide shared decision making.
- Subjects
METASTASIS; RENAL cell carcinoma; CANCER treatment; CANCER patients; NEPHRECTOMY; ONCOLOGIC surgery; COMBINED modality therapy; KIDNEY tumors; EVIDENCE-based medicine; PROFESSIONAL practice; TREATMENT effectiveness; PATIENT selection
- Publication
Cancer (0008543X), 2018, Vol 124, Issue 18, p3641
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.31341