We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Susceptibility to leprosy is linked to the human NRAMP1 gene.
- Authors
Abel, Laurent; Sánchez, Fabio O.; Oberti, Jean; Thuc, Nguyen V.; Hoa, Le Van; Lap, Vu D.; Skamene, Emil; Lagrange, Philippe H.; Schurr, Erwin; Abel, L; Sánchez, F O; Oberti, J; Thuc, N V; Hoa, L V; Lap, V D; Skamene, E; Lagrange, P H; Schurr, E
- Abstract
Leprosy is a debilitating infectious disease of human skin and nerves. Genetic factors of the host play an important role in the manifestation of disease susceptibility. The human NRAMP1 gene is a leprosy susceptibility candidate locus since its murine homologue Nramp1 (formerly Lsh/Ity/Bcg) controls innate resistance to Mycobacterium lepraemurium. In this study, 168 members of 20 multiplex leprosy families were genotyped for NRAMP1 alleles and 4 closely linked polymorphic markers. Highly informative haplotypes overlapping the NRAMP1 gene were constructed, and the haplotype segregation into leprosy-affected offspring was analyzed. It was observed that the segregation of NRAMP1 haplotypes into affected siblings was significantly nonrandom. This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 1, p133
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/513830