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- Title
Immunity To Onchocerciasis: Putative Immune Persons Produce A Thl-Like Response To Onchocerca Volvulus.
- Authors
Elson, Lynne H.; Calvopina H., Manuel; Paredes Y., Wilson; Araujo N., Edmundo; Bradley, Janette E.; Guderian, Ronald H.; Nutman, Thomas B.
- Abstract
Immunity to Onchocerca volvulus (Ov) infection is suggested by the presence of putatively immune (PI) subjects in a region of Ecuador in which Ov is endemic. PI subjects were identified by traditional diagnostic methods combined with a polymerase chain reaction-based assay for Ov DNA in skin snips. Responses of peripheral blood mononuclear cells (PBMC) from the PI group (n = 16) were compared with those of persons with active infection (microfiladermic [MF] subjects; n = 51). PBMC of PI subjects proliferated significantly more to Ov antigen (OvAg; P < .009) than did PBMC ofMF persons but less to streptolysin-O (P < .001). Cytokine analysis of PBMC culture supernatants revealed that PI subjects (n = 11) produced significantly more interferon-ã to OvAg than did those in the MF group (n = 18; P = .018), less interleukin (IL)-5 to nonparasite antigen (P = .003) and mitogen (P = .012), and less IL-I0 spontaneously (P = .016). Thus, immunity to Ov may in part be mediated by an antigen-specific Th I-type response.
- Publication
Journal of Infectious Diseases, 1995, Vol 171, Issue 3, p652
- ISSN
0022-1899
- Publication type
Article