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- Title
Mixed chimerism post haematopoietic stem cell transplantation in JMML: Interventions and outcome.
- Authors
Gabelli, Maria; Balasch‐Carulla, Milena; Rao, Anupama; Adams, Stuart; Kricke, Susanne; Mirci Danicar, Oana; Palmer, Rebecca; Wynn, Robert; Bonney, Denise; Patrick, Katharine; Vora, Ajay; Rao, Kanchan; Lucchini, Giovanna
- Abstract
Keywords: graft versus leukaemia effect; haematopoietic stem cell transplantation; interferon alpha; juvenile myelomonocytic leukaemia; mixed chimerism EN graft versus leukaemia effect haematopoietic stem cell transplantation interferon alpha juvenile myelomonocytic leukaemia mixed chimerism e34 e36 3 11/24/22 20221201 NES 221201 Juvenile myelomonocytic leukaemia (JMML) is an aggressive disorder of childhood, characterized by clonal evolution of the myelomonocytic populations, driven by mutations in five genes ( I PTPN11, KRAS, NRAS, CBL, NF1 i ).1 For most patients, the only curative option is allogeneic haematopoietic stem cell transplantation (HSCT). IFN administration increased or stabilized donor chimerism in the CD3 compartment but not in the CD15/14 (Table S3); all patients relapsed and underwent a second HSCT. At a median follow up of 4 years from diagnosis, 20/27 (74%) patients are alive in CR, five patients died of disease progression and two of transplant-related mortality (TRM) following second HSCT.
- Subjects
HEMATOPOIETIC stem cell transplantation; CHIMERISM; STEM cell transplantation
- Publication
British Journal of Haematology, 2022, Vol 199, Issue 5, pe34
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18474