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- Title
Frequent somatic mutations of KMT2D (MLL2) and CARD11 genes in primary cold agglutinin disease.
- Authors
Małecka, Agnieszka; Trøen, Gunhild; Tierens, Anne; Østlie, Ingunn; Małecki, Jędrzej; Randen, Ulla; Wang, Junbai; Berentsen, Sigbjørn; Tjønnfjord, Geir E.; Delabie, Jan M. A.
- Abstract
The article presents a study which determined the molecular changes in primary cold agglutinin disease (CAD)-associated lymphoproliferative disease of bone marrow that may be used in disease diagnosis or targeted treatment. Also cited are the studies showing that CAD patients have unique low-grade clonal B-cell lymphoproliferative disease, and the use of exome sequencing to determine the recurrent somatic mutations of KMT2D and CARD11 genes.
- Subjects
COLD agglutinin syndrome; LYMPHOPROLIFERATIVE disorders; BONE marrow diseases; B cells; GENETIC mutation
- Publication
British Journal of Haematology, 2018, Vol 183, Issue 5, p838
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.15063