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- Title
Hepatic left lobe volume is a sensitive index of metabolic improvement in obese women after gastric banding.
- Authors
Giannetti, M; Piaggi, P; Ceccarini, G; Mazzeo, S; Querci, G; Fierabracci, P; Salvetti, G; Galli, G; Ricco, I; Martinelli, S; Di Salvo, C; Anselmino, M; Landi, A; Vitti, P; Pinchera, A; Santini, F
- Abstract
BACKGROUND:Nonalcoholic fatty liver disease is a common finding in obese subjects. Increasing evidence has been provided suggesting that it represents the hepatic component of the metabolic syndrome.OBJECTIVE:Aim of this longitudinal study was to evaluate the relationships between several anthropometric measures, including the hepatic left lobe volume (HLLV), and various indicators of the metabolic syndrome in a cohort of severely obese women before and after laparoscopic adjustable gastric banding (LAGB).STUDY DESIGN AND RESULTS:Seventy-five obese women (mean age 45±10 years and body mass index (BMI) 42.5±4.8 kg m−2) underwent LAGB and completed an average (±s.d.) post-surgical follow-up of 24±6 months. Determination of HLLV, subcutaneous and intra-abdominal fat (IAF) was based on ultrasound. The principal component statistical analysis applied to pre-operative measurements, highlighted HLLV as a parameter that clustered with serum insulin, IAF, serum glucose and uric acid, along with triglycerides (TGs), alkaline phosphatase and high-density lipoprotein cholesterol. After LAGB, the average reduction of BMI was 23%, 12% for subcutaneous fat (SCF), 42% for HLLV and 40% for visceral fat. Among body weight, BMI, SCF, IAF and HLLV, reduction of the latter was an independent predictor of reduction of serum transaminases and γ-Glutamyltransferase, glucose, insulin and TGs.CONCLUSIONS:In severely obese women: (i) HLLV is a sensitive indicator of ectopic fat deposition, clustering with parameters defining the metabolic syndrome; (ii) weight loss achieved by LAGB is associated with a reduction of liver volume as estimated by HLLV; (iii) among various anthropometric parameters measured, reduction of HLLV that follows LAGB represents the best single predictor of improvement of various cardiometabolic risk factors.
- Subjects
OBESITY in women; FATTY liver; GASTRIC bypass; METABOLIC syndrome; BODY mass index; LONGITUDINAL method
- Publication
International Journal of Obesity, 2012, Vol 36, Issue 3, p336
- ISSN
0307-0565
- Publication type
Article
- DOI
10.1038/ijo.2011.243