We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Lack of Association between the IL13 Variant Arg110Gln and Susceptibility to Cedar Pollinosis in a Japanese Population.
- Authors
Cheng, Lei; Hirota, Tomomitsu; Enomoto, Tadao; Tamari, Mayumi; Akahoshi, Mitsuteru; Matsuda, Akira; Shimizu, Makiko; Takahashi, Naomi; Enomoto, Keisuke; Yamasaki, Akiko; Mao, Xiao-Quan; Hopkin, Julian M.; Shirakawa, Taro
- Abstract
Background: Interleukin (IL)-13 has come to be appreciated as a molecule critically involved in allergic inflammatory responses. Recent studies revealed that a common variant in the coding region of the IL13 gene, Arg 110Gln, has been implicated in the development of asthma and atopy. Methods: To assess whether the IL13 variant Arg 110Gln is associated with cedar pollinosis, one of the most common atopic diseases in the Japanese population, we examined the Arg 110Gln variant using PCR-RFLP to compare the genotype and allele frequencies between 95 patients with cedar pollinosis and 95 healthy control subjects. Relationships between the Arg 110Gln variant and the pollinosis-related traits, e.g. rhinitis severity, eosinophil counts in nasal secretion and serum total and allergen-specific IgE levels, were also investigated. Results: The frequencies of the minor allele Gln110 were 25.8% in patients with cedar pollinosis and 30.9% in healthy control subjects (p > 0.05). There was also no significant difference in the genotype frequencies between cases and controls (p > 0.05). In addition, we found no significant association of the Arg110Gln variant with any of the pollinosis-related phenotypes (p > 0.05). Conclusions: Our data suggest lack of evidence for identifying the variant Arg110Gln at the IL13 locus as a genetic risk factor involved in the development of Japanese cedar pollinosis.
- Subjects
JAPAN; INTERLEUKIN-13; GENETIC polymorphisms; OBSTRUCTIVE lung diseases; SERUM; CYTOKINES
- Publication
International Archives of Allergy & Immunology, 2006, Vol 139, Issue 1, p25
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000089519