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- Title
Episodes of Severe Hypoglycemia in Type 1 Diabetes Are Preceded and Followed within 48 Hours by Measurable Disturbances in Blood Glucose.
- Authors
DESIDERI, GIOVAMBATTISTA; MARINUCCI, MARIA CONTINA; TOMASSONI, GIANLUCA; MASCI, PIER GIORGIO; SANTUCCI, ANNA; FERR, CLAUDIO
- Abstract
Up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and reduced nitric oxide (NO) availability represent early characteristics of atherosclerosis. To evaluate whether the antioxidant vitamin E affected the circulating levels of soluble VCAM-1 (sVCAM-1) and the plasma metabolite of NO (nitrite+nitrate) in hypercholesterolemic patients, either vitamin E (either 400 IU or 800 IU/d for 8 wk) or placebo were randomly, double-blindly given to 36 hypercholesterolemic patients and 22 age- and sex-matched controls. At baseline hypercholesterolemic patients showed higher plasma sVCAM-1 (microg.liter -1) (591.2 ±132.5 vs. 505.0 ± 65.6, P < 0.007) and lower NO metabolite (microM) levels (15.9 ± 3.4 vs. 29.2 ± 5.1, P < 0.0001) than controls. In hypercholesterolemic patients, 8 wk vitamin E (but not placebo) treatment significantly decreased circulating sVCAM-1 levels (400 IU: -148.9 ± 84.6, P < 0.009; 800 IU: -204.0±75.7, P < 0.0001; placebo: -4.7 ± 22.6, NS), whereas it increased NO metabolite concentrations (400 IU: +4.0 ± 1.7, P < 0.02; 800 IU: +5.5 ± 0.8, P < 0.0001; placebo: +0.1 ±1.1, NS) without affecting circulating low- density lipoprotein levels. Changes in both plasma sVCAM-1 and NO metabolite levels showed a trend to significantly correlate (r = -0.515, P = 0.010; and r = 0.435, P = 0.034, respectively) with changes in vitamin E concentrations induced by vitamin E supplementation. In conclusion, isolated hypercholesterolemia both increased circulating sVCAM-1 and reduced NO metabolite concentrations. Vitamin E supplementation counteracts these alterations, thus representing a potential tool for endothelial protection in hypercholesterolemic patients.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2002, Vol 87, Issue 6, p2940
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jcem.87.6.8545