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- Title
Serum Insulin-Like Growth Factor I (IGF-I), IGF-Binding Protein-1 and -3, and the Acid-Labile Subunit as Serum Markers of Body Composition during Growth Hormone (GH) Therapy in Adults with GH Deficiency*.
- Authors
THORÉN, MARJA; HILDING, AGNETA; BAXTER, ROBERT C.; DEGERBLAD, MARIE; WIVALL-HELLERYD, INGA-LENA; HALL, KERSTIN
- Abstract
Serum levels of insulin-like growth factor I (IGF-I), IGF-binding protein-3 (IGFBP-3), the acid-labile subunit (ALS), insulin, and IGFBP-1 were evaluated as indicators of body composition during GH replacement therapy in 20 GH-deficient patients (9 women and 11 men), aged 22–57 yr, with IGF-I levels below −2 SD. The mean GH dose was 0.128 ± 0.003 IU/kg·week during the first month and thereafter 0.23 ± 0.01 IU/kg·week, divided into daily doses (0.7–4.3 IU/day). Serum levels of IGF-I, ALS, and IGFBP-3 above the normal range were reached in seven, five, and three subjects, respectively, after 12 months of GH therapy. IGF-I and ALS levels, but not IGFBP-3 levels, correlated with the total daily GH dose (r = 0.676; P = 0.001 and r = 0.631; P= 0.003). The mean increase in lean body mass (LBM) measured by dual energy x-ray absorptiometry was 3.0 ± 0.5 kg (P < 0.001). At 12 months, the LBM values were significantly correlated to the IGF-I levels (r = 0.718; P < 0.001), but not to ALS or IGFBP-3 levels. No correlation was found before therapy, and the increase in LBM at 12 months correlated with the IGF-I increase (r = 0.514; P = 0.029) only after exclusion of two nonresponders. Both before and during therapy, LBM was inversely related to IGFBP-1 (r = −0.715; P < 0.004 at 12 months). None of the GH-induced proteins could be used as indicators of body fat changes. In conclusion, both IGF-I and ALS can be used as indicators to avoid GH excess during replacement therapy, but only IGF-I relates to changes in LBM.
- Publication
Journal of Clinical Endocrinology & Metabolism, 1997, Vol 82, Issue 1, p223
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jcem.82.1.3698