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- Title
Single-chromosome transcriptional profiling reveals chromosomal gene expression regulation.
- Authors
Levesque, Marshall J; Raj, Arjun
- Abstract
We report intron chromosomal expression FISH (iceFISH), a multiplex imaging method for measuring gene expression and chromosome structure simultaneously on single chromosomes. We find substantial differences in transcriptional frequency between genes on a translocated chromosome and the same genes in their normal chromosomal context in the same cell. Correlations between genes on a single chromosome pointed toward a cis chromosome-level transcriptional interaction spanning 14.3 megabases.
- Subjects
CHROMOSOME abnormalities; CHROMOSOMAL proteins; GENETICS; GENE expression; CHROMOSOMES
- Publication
Nature Methods, 2013, Vol 10, Issue 3, p246
- ISSN
1548-7091
- Publication type
Article
- DOI
10.1038/nmeth.2372