The article reports on highlights of the June 2008 meeting of the American Society for Mass Spectrometry (ASMS) which focused on mass spectrometry instrumentation aimed at identification of protein biomarkers. Waters Corp. has launched the Xevo TQ MS tandem quadrupole mass spectrometry system. Agilent Technologies has introduced the 6400 series of triple quadrupole liquid chromatography-mass spectrometry systems with increased sensitivity.