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- Title
Systems genetics approach reveals cross-talk between bile acids and intestinal microbes.
- Authors
Fu, Jingyuan; Kuipers, Folkert
- Abstract
The emerging role of the gut microbiome in human pathophysiology has led to a paradigm shift in our view of complex traits, moving us from a "genetics-environment" interaction model to one that encompasses "genetics-microbes-environment." These shared QTLs highlighted genetic effects on the gut microbes and BA via pleiotropic (QTL -> microbe and QTL -> BA independently) or causal effects (QTL -> BA -> Microbe or QTL -> Microbe -> BA) (Fig 1). DIAGRAM: Fig 1: Systems quantitative trait locus (QTL) analysis on gut microbes and BA profiles. baQTL indicates a QTL associated to BA; miQTL indicates a QTL associated to gut microbes; sharedQTL indicates a QTL associated to both BA and gut microbes.
- Subjects
GENETICS; BILE acids; BILE; GASTROINTESTINAL system physiology; MICROORGANISMS; FARNESOID X receptor; BIOLOGICAL crosstalk
- Publication
PLoS Genetics, 2019, Vol 15, Issue 8, p1
- ISSN
1553-7390
- Publication type
Article
- DOI
10.1371/journal.pgen.1008307