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- Title
Synergistic activation of Toll-like receptor 8 by two RNA degradation products.
- Authors
Geyer, Matthias; Pelka, Karin; Latz, Eicke
- Abstract
The article discusses the toll-like receptor (TLR) 8 activation which recognizes the ribonucleic acid (RNA) degradation elements. Topics discussed include the study of Shimizu and colleagues on the crystal structure of TLR8 in relation with single-stranded (ss) RNA, the improvement of synergistic binding of uridine, and the therapeutic use of TLRs 7 or 8 in several autoimmune disease.
- Subjects
TOLL-like receptors; RNA analysis; URIDINE; AUTOIMMUNE disease treatment; CRYSTAL structure
- Publication
Nature Structural & Molecular Biology, 2015, Vol 22, Issue 2, p99
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb.2967