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- Title
Atipik Antipsikotiklere Bağlı GeliŞen Diyabetin Mekanizması.
- Authors
Yurtsever, Fatma; Esen-Danacı, Ayşen; Deveci, Artuner
- Abstract
New researches and case reports have revealed that diabetes incidence is higher in patients treated with new generation antipsychotics. The incidence of diabetes is 2-3 fold in schizophrenic patients compared to normal population. It is confuses that the use of new generation antipsychotics increases the risk of diabetes and cardiovascular diseases related to it. With the use of new generation antipsycotics onset age of diabetes went under 40 years in patients with schizophrenia. Even though the mechanism of diabetes caused by new generation antipsychotics is unclear some hypotheses include mechanisms related with dopamine receptor antagonism, increase in body weight, histamine 1 and 5-HT2A or 5-HT2C receptor antagonism, increase in serum leptin, insulin resistance and direct effects on pancreas. We reviewed the evidence regarding the diabetogenic effects of new generation antipsychotics and possible underlying mechanisms of this effect.
- Subjects
DIABETES; ANTIPSYCHOTIC agents; PEOPLE with schizophrenia; CARDIOVASCULAR diseases; DOPAMINE; HISTAMINE; DRUG antagonism
- Publication
Klinik Psikofarmakoloji Bulteni, 2007, Vol 17, Issue 1, p34
- ISSN
1017-7833
- Publication type
Article