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- Title
ppGpp: magic beyond RNA polymerase.
- Authors
Dalebroux, Zachary D.; Swanson, Michele S.
- Abstract
During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and its impact on promoter selection by RNAP, we discuss how bacteria exploit ppGpp to modulate the synthesis, stability or activity of proteins or regulatory RNAs that are crucial in challenging environments, using mechanisms beyond the direct regulation of RNAP activity.
- Subjects
PSYCHOLOGICAL stress; RNA polymerases; GENES; CELLULAR recognition; SINGLE cell proteins
- Publication
Nature Reviews Microbiology, 2012, Vol 10, Issue 3, p203
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2720