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- Title
Innate immunity: TRIM5α: the tie that binds.
- Authors
van Ooij, Christiaan
- Abstract
The article highlights a research conducted by A. Kirmaier and colleagues regarding the transmission of simian immunodeficiency virus (SIV) in the U.S. The cross-species transmission of SIV has seen a rise to HIV-1 and HIV-2 in humans. The tripartite motif protein 5a (TRIM5a), which is part of the host intrinsic immune system, can prevent cross-species transmission of SIV. Thus, the restriction of retroviral growth by TRIM5a acts as a vital barrier to the spread of retroviruses.
- Subjects
UNITED States; INFECTIOUS disease transmission; HIV; SIV antibodies; VIRUS inhibitors; IMMUNE system; RETROVIRUSES
- Publication
Nature Reviews Microbiology, 2010, Vol 8, Issue 10, p677
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro2447