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- Title
Alkyltelluro Substitution Improves the Radical-Trapping Capacity of Aromatic Amines.
- Authors
Poon, Jia‐fei; Yan, Jiajie; Singh, Vijay P.; Gates, Paul J.; Engman, Lars
- Abstract
The synthesis of a variety of aromatic amines carrying an ortho-alkyltelluro group is described. The new antioxidants quenched lipidperoxyl radicals much more efficiently than α-tocopherol and were regenerable by aqueous-phase N-acetylcysteine in a two-phase peroxidation system. The inhibition time for diaryl amine 9 b was four-fold longer than recorded with α-tocopherol. Thiol consumption in the aqueous phase was found to correlate inversely to the inhibition time and the availability of thiol is the limiting factor for the duration of antioxidant protection. The proposed mechanism for quenching of peroxyl radicals involves O-atom transfer from peroxyl to Te followed by H-atom transfer from amine to alkoxyl radical in a solvent cage.
- Subjects
ANTIOXIDANTS; AROMATIC amines; ORGANOTELLURIUM compounds; SUBSTITUTION reactions; VITAMIN E deficiency
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 36, p12891
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201602377