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- Title
The Difference between Preprandial and Postprandial Rabeprazole Dosing on Helicobacter pylori Eradication Efficacy.
- Authors
Jae Yeong Cho; Dae Young Cheung; Sunah Suk; Soo Yeon Choi; Yun Jung Park
- Abstract
Background/Aims Thirty minutes preprandial dosing has been considered a prerequisite for proper proton pump inhibitor (PPI) effect. Preprandial intake is quite bothersome. Rabeprazole has recently been proved to use postprandially as well as preprandial dosing. We investigated the Helicobacter eradication efficacy of postprandial rabeprazole dosing compared to preprandial PPI regimen. Methods Study was conducted by review of electronic medical record of patients who received triplet regimen (rabeprazole, amoxicillin, and clarithromycin) at an academic institute, Seoul, from January 2016 to January 2019. Results A total of 340 subjects were enrolled consecutively. Eight-six subjects were excluded due to incomplete data profiles. Finally, 254 subjects were included in the analysis. One hundred and thirty-five subjects (control group) were treated with pre-prandial rabeprazole and 119 subjects (test group) were with postprandial dose. The mean ages were 52.6±12.5 years old for the control group and 56.1±11.9 for the test group. The male to female ratios were 1.65 (84/51) for the control group and 1.90 (78/41) for the test group. Helicobacter pylori eradication was successful in 79.2% in total. In control group 79.3% was successful and in test group 79.2% was successful (p=0.474). In subgroup analysis, the 14-day regimen showed better eradication success rate than 7-day regimen, 85.5%, and 72.8% respectively, but statistical significance was not achieved (p=0.55). Gender, smoking, alcohol, and comorbidities have no impact on eradication efficacy. Conclusions For H. pylori eradication, postprandial rabeprazole dosing results in a comparable success rate to pre-prandial dosing in a rabeprazole-amoxicillin-clarithromycin combination regimen.
- Subjects
SEOUL (Korea); HELICOBACTER pylori; ELECTRONIC health records; PROTON pump inhibitors
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p121
- ISSN
1976-2283
- Publication type
Article