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- Title
Inhibition of SNARE-driven neuroexocytosis by plant extracts.
- Authors
Chang Hwa Jung; Yoo Soo Yang; Jun-Seob Kim; Yeon-Kyun Shin; Jae Sung Hwang; Eui Dong Son; Hong Hwa Lee; Koo Min Chung; Jung Mi Oh; Jong Hwa Lee; Kweon, Dae-Hyuk
- Abstract
Neuronal soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor (SNARE) proteins mediate membrane fusion between synaptic vesicle and presynaptic membrane, resulting in neurotransmitter release. SNARE proteins are specific substrates of botulinum neurotoxins (BoNT) which are now widely used for therapeutic and cosmetic purposes. While BoNT blocks neuroexocytosis by cleaving SNAREs, inhibiting SNARE assembly process might exert the same effect on neurotransmission. In the present study, some extracts of 100 plants reduced neurotransmitter release by inhibiting SNARE complex formation in neuronal cells. The extracts effectively paralyzed muscle of rat phrenic nerve-hemidiaphragm preparation. Our results raise the possibility that SNARE folding inhibitors from natural resources might replace some special BoNT application fields.
- Subjects
CELL junctions; MEMBRANE fusion; NEURAL transmission; CELL membranes; PROTEINS; BOTULINUM toxin
- Publication
Biotechnology Letters, 2009, Vol 31, Issue 3, p361
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1007/s10529-008-9878-z