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- Title
Treatment of perianal Paget's disease using photodynamic therapy with assistance of fluorescence examination: case report.
- Authors
Libo Li; Yongjian Deng; Lanying Zhang; Wangjun Liao; Rongcheng Luo; Zheng Huang; Li, Libo; Deng, Yongjian; Zhang, Lanying; Liao, Wangjun; Luo, Rongcheng; Huang, Zheng
- Abstract
Our aim was to determine the usefulness of fluorescence examination and photodynamic therapy (PDT) for the management of perianal extramammary Paget's disease. A 75-year-old woman underwent two courses of PDT. The first treatment was carried out with topically applied 5-aminolevulinic acid (ALA) to the affected area (2.5 x 2.5 cm(2)) 3 h before light treatment. We used ALA/protoporphyrin IX (PpIX)-mediated fluorescence to visualize the lesion and its margins. The lesion was treated with a 630 nm laser at 120 J/cm(2). Forty days later, the residual lesion was given a second treatment at the same light dose after topical application of ALA and intravenous injection of HiPorfin. ALA/PpIX-mediated fluorescence served as a useful tool to visualize the lesion's location. Complete cure was achieved after the second course of PDT. During 7 months of follow up, no recurrence, scarring or functional loss was noticed. We concluded that ALA-assisted fluorescence examination can be a useful tool to determine the lesion and its margins. ALA-PDT is effective for superficial lesions, but, for thicker and deeper lesions, the systemic administration of photosensitizer is needed.
- Subjects
PHOTOCHEMOTHERAPY; CASE studies; RADIOACTIVITY; INTRAVENOUS therapy; OLDER women; PHOTOTHERAPY
- Publication
Lasers in Medical Science, 2009, Vol 24, Issue 6, p981
- ISSN
0268-8921
- Publication type
journal article
- DOI
10.1007/s10103-009-0653-8