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- Title
Electrophilically Activated Nitroalkanes in Synthesis of 3,4-Dihydroquinozalines.
- Authors
Aksenov, Alexander V.; Grishin, Igor Yu.; Aksenov, Nicolai A.; Malyuga, Vladimir V.; Aksenov, Dmitrii A.; Nobi, Mezvah A.; Rubin, Michael
- Abstract
Nitroalkanes activated with polyphosphoric acid serve as efficient electrophiles in reactions with various nucleophilic amines. Strategically placed second functionality allows for the design of annulation reactions enabling preparation of various heterocycles. This strategy was employed to develop an innovative synthetic approach towards 3,4-dihydroquinazolines from readily available 2-(aminomethyl)anilines.
- Subjects
NITROALKANES; NUCLEOPHILIC reactions; POLYPHOSPHORIC acid; ANNULATION; ELECTROPHILES
- Publication
Molecules, 2021, Vol 26, Issue 14, p4274
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules26144274