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- Title
Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations.
- Authors
Baek, Jiwon; Lee, Tae Kyoung; Kim, Ki Hyun; Song, Jae-Hyoung; Ko, Hyun-Jeong; Choi, Eunyong; Kim, Seon-Hee; Lee, Sanghyun; Choi, Sang Un; Lee, Seong; Yoo, Sang-Woo
- Abstract
<italic>Lespedeza cuneata</italic> (Fabaceae), known as Chinese bushclover, has been used in traditional medicines for the treatment of diseases including diabetes, hematuria, and insomnia. As part of a continuing search for bioactive constituents from Korean medicinal plant sources, phytochemical analysis of the aerial portion of <italic>L. cuneata</italic> led to the isolation of two new lignan glycosides (<bold>1</bold>,<bold>2</bold>) along with three known lignan glycosides (<bold>3</bold>–<bold>7</bold>) and nine known flavonoid glycosides (<bold>8</bold>–<bold>14</bold>). Numerous analysis techniques, including 1D and 2D NMR spectroscopy, CD spectroscopy, HR-MS, and chemical reactions, were utilized for structural elucidation of the new compounds (<bold>1</bold>,<bold>2</bold>). The isolated compounds were evaluated for their applicability in medicinal use using cell-based assays. Compounds <bold>1</bold> and <bold>4</bold>–<bold>6</bold> exhibited weak cytotoxicity against four human breast cancer cell lines (Bt549, MCF7, MDA-MB-231, and HCC70) (IC50 < 30.0 μM). However, none of the isolated compounds showed significant antiviral activity against PR8, HRV1B, or CVB3. In addition, compound <bold>10</bold> produced fewer lipid droplets in Oil Red O staining of mouse mesenchymal stem cells compared to the untreated negative control without altering the amount of alkaline phosphatase staining.
- Subjects
LESPEDEZA cuneata; GLYCOSIDES; FAT cells; OSTEOBLASTS; PHYTOCHEMICALS
- Publication
Molecules, 2018, Vol 23, Issue 8, p1920
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23081920