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- Title
Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines.
- Authors
Ying Fu; Jing-Yi Wang; Dong Zhang; Yu-Feng Chen; Shuang Gao; Li-Xia Zhao; Fei Ye
- Abstract
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, 1H-NMR, 13C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification.
- Subjects
CHEMICAL synthesis; SULFONYLUREAS; THIAZOLINES; HETEROCYCLIC compounds; CORN disease &; pest prevention
- Publication
Molecules, 2017, Vol 22, Issue 10, p1601
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22101601