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- Title
A Retrospective Analysis of Thalidomide Therapy in Non-HIV-Related Kaposi’s Sarcoma.
- Authors
Ben M’barek, Lilia; Fardet, Laurence; Mebazaa, Amel; Thervet, Eric; Biet, Israel; Kérob, Delphine; Morel, Patrice; Lebbe, Céleste
- Abstract
Background: Thalidomide has antiangiogenic and immunomodulatory properties and has recently been used in the management of human malignancies. Several studies have suggested its interest for treating AIDS-related Kaposi’s sarcoma. Objectives: This study aimed to assess the efficacy and toxicity of thalidomide, an antiangiogenic agent, for the treatment of non-HIV-related Kaposi’s sarcoma. Methods: Eleven patients were included in this retrospective study conducted in the Department of Dermatology of Saint Louis, Paris, between 2000 and 2003. Among them, 2 were immunosuppressed (1 renal transplant recipient and 1 patient with microscopic polyangiitis treated by oral steroids) with stable immunosuppressive regimens during the past 6 months. The median daily thalidomide dosage was 100 mg and the median duration of drug treatment was 16 weeks. Results: Three patients achieved a partial response and 4 had a stable disease. Although no grade 3 or 4 was observed, 3 (27%) out of 11 patients prematurely discontinued thalidomide because of grade 1 sensory neuropathy (paresthesia) and vertigo. Conclusions: Our results show a true although modest interest of thalidomide in non-HIV-related Kaposi’s sarcoma and prompt us to evaluate less toxic thalidomide analogues for this indication. Copyright © 2007 S. Karger AG, Basel
- Publication
Dermatology (10188665), 2007, Vol 215, Issue 3, p202
- ISSN
1018-8665
- Publication type
Article
- DOI
10.1159/000106576