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- Title
A Phase II Trial of Weekly High-Dose Folinic Acid and 5-Fluorouracil in Combination with Epirubicin as Salvage Chemotherapy in Advanced Breast Cancer.
- Authors
Stöger, H.; Schmid, M.; Bauernhofer, T.; Moser, R.M.; Ploner, F.; Derstvenscheg, E.; Kasparek, A.K.; Kuss, I.; Wilders-Truschnig, M.; Lackner, C.; Steindorfer, P.; Samonigg, H.
- Abstract
Twenty-five patients with advanced breast cancer (ABC) who had failed from first-line chemotherapy entered into a phase II study employing weekly 5-fluorouracil (FU) 350 mg/m2, folinic acid (FA) 500 mg/m2, and epirubicin (EPI) 35 mg/m2, for a maximum of 18 cycles. Twenty-three patients were evaluable for response. One achieved a complete response and 7 showed a partial response, for an objective response rate of 35%; 7 (31%) patients achieved a stabilization of the disease, while 8 (35%) patients progressed under treatment. The median duration of response was 6 months and median survival amounted to 10.6 months. Side effects were in general mild with grade III leukopenia in 5 patients and grade IV leukopenia in 1 patient. Other toxicity included nausea and vomiting (88%), diarrhea (26%), stomatitis (40%) and alopecia (84%), but all of them mainly restricted to WHO grade I and II. Our results suggest that the combination of high-dose FA, FU, and EPI can be safely administered in the investigated schedule and represents an attractive alternative in the search for second-line therapies that combine effectiveness with acceptable toxicity in the treatment of refractory ABC. Copyright © 1994 S. Karger AG, Basel
- Publication
Oncology, 1994, Vol 51, Issue 6, p518
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000227397