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- Title
Synthesis and Antiviral Activity of Glycyrrhizic-Acid Conjugates with Aromatic Amino Acids.
- Authors
Baltina, L.; Fairushina, A.; Eropkin, M.; Konovalova, N.; Petrova, P.; Eropkina, E.
- Abstract
Amino-acid conjugates of glycyrrhizic acid (GA) containing phenylalanine, tyrosine, and tryptophan in the carbohydrate and triterpene parts were synthesized using N-hydroxybenzotriazole (HOBt)-N,N′-dicyclohexylcarbodiimide (DCC) and sodium salts of the amino acids. GA conjugates containing two aminoacid residues in the glycoside carbohydrate part were synthesized using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The GA conjugate with tyrosine exhibited weak but consistent antiviral activity against flu virus A/St.-Petersburg/05/09 (H1N1)pdm09 that was similar to the standard strain A/California/07/09 and pronounced antiviral activity against respiratory-syncytial virus (RSV) and herpes simplex virus (HSV-1).
- Subjects
ORGANIC acids; CHEMICAL synthesis; ANTI-infective agents; AMINO acids; SODIUM salts; ANTIVIRAL agents
- Publication
Chemistry of Natural Compounds, 2017, Vol 53, Issue 6, p1096
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-017-2209-7