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- Title
Determination of liver fibrosis stages in Egyptian chronic hepatitis B patients by a noninvasive tool.
- Authors
SERAG, Waleed Mohamed; MOHAMED, Magdy Mahmoud; ELSAYED, Basem Eysa; ABD-ELHAMED, Sara Mahmoud
- Abstract
Background/aim: Hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF). The prognosis and management of patients with chronic hepatitis B virus depend on the amount and progression of liver fibrosis. Angiopoietin-like protein 2 (Angptl2) is not only a chronic inflammatory mediator, but also a tissue-remodeling factor. The aim of this study is to explore the predictive value of Angptl2 in different fibrosis stages in patients chronically infected with HBV. Materials and methods: Eighty patients with chronic HBV infection undergoing Fibroscan were included. Serum concentrations of Angptl2 were detected using a commercial ELISA kit. Results: Angptl2 levels were significantly associated with liver fibrosis stages (P = 0.02). The area under the curve (AUC) of Angptl2 for distinguishing patients who showed significant fibrosis (F2-F4) was 70.2%. Angptl2 with fibrosis-4 (FIB-4) and Angptl2 with AST/platelets ratio (APRI) performed best with an AUC of 92.5%. Conclusion: In patients with chronic HBV infection, Angptl2 level represents a potential biomarker independently associated with fibrosis stages. The combination of Angptl2 with FIB-4 or Angptl2 with APRI performed better than the existing models for diagnosing significant fibrosis.
- Subjects
CHRONIC hepatitis B; FIBROSIS; ANGIOPOIETIN-like proteins; HEPATITIS B virus; LIVER; INFLAMMATORY mediators
- Publication
Turkish Journal of Medical Sciences, 2019, Vol 49, Issue 4, p1145
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-1812-165